Combine Ingredients: In a large bowl, mix the ground beef with soy sauce, Worcestershire sauce, brown sugar, liquid smoke (if using), garlic powder, onion powder, black pepper, and cayenne pepper. Ensure the mixture is well combined.
Marinate: Cover the bowl and let the mixture marinate in the refrigerator for at least 2 hours, preferably overnight.
Prepare Jerky Gun: If you have a jerky gun, fill it with the ground beef mixture. Alternatively, you can form the jerky by hand or with a rolling pin and cookie cutters.
Shape Jerky: Create thin strips or shapes with the ground beef mixture.
Dehydrate: Place the jerky pieces on dehydrator trays, leaving space between them for airflow. Dehydrate at 160°F (71°C) for 4 to 6 hours, or until the jerky is fully dried.
Cool and Store: Let the jerky cool completely before storing it in an airtight container.
