Prepare the Marinade: In a bowl, combine soy sauce, honey, brown sugar, Worcestershire sauce, minced garlic, apple cider vinegar, onion powder, black pepper, red chili flakes, and smoked paprika. Whisk until well combined.
Marinate the Beef: Place the beef slices in a large resealable bag. Pour the marinade over the beef, ensuring all pieces are well-coated. Seal the bag and marinate in the refrigerator for at least 4 hours, preferably overnight.
Dry the Beef: Preheat your oven to 175°F (80°C). Remove the beef from the marinade and pat dry with paper towels. Arrange the beef slices in a single layer on a wire rack placed over a baking sheet.
Bake the Jerky: Place the rack in the oven and bake for 3-4 hours, or until the beef reaches your desired level of dryness.
Cool and Store: Allow the jerky to cool completely. Store in an airtight container in a cool, dry place for up to 2 weeks.