Prepare Beef: Cut the beef brisket into thin, uniform strips. Partial freezing can make this easier.
Create Marinade: In a bowl, mix soy sauce, Worcestershire sauce, brown sugar, apple cider vinegar, liquid smoke (if using), onion powder, garlic powder, and black pepper.
Marinate Beef: Place the beef strips in the marinade, ensuring they are fully coated. Refrigerate and let marinate for at least 4 hours, preferably overnight.
Smoker Setup: Preheat your smoker to 160°F (71°C). Add your choice of wood chips.
Smoke Beef: Arrange the beef strips on the smoker racks, leaving space between them for airflow. Smoke for 4 to 6 hours, or until the jerky reaches your desired level of dryness and chewiness.
Cool and Store: Remove the jerky from the smoker, let it cool completely, and store in an airtight container.