Slice Beef: Cut the beef into thin, even strips against the grain for the best texture.
Mix Marinade: In a bowl, whisk together soy sauce, Worcestershire sauce, brown sugar, apple cider vinegar, garlic powder, onion powder, black pepper, and cayenne pepper.
Marinate Beef: Place the beef strips in the marinade, making sure they are fully coated. Marinate in the refrigerator for at least 4 hours, preferably overnight.
Oven Preparation: Preheat your oven to 175°F (80°C). Line a baking sheet with parchment paper and place a wire rack on top.
Arrange Beef: Lay the marinated beef strips on the wire rack, ensuring they don't touch each other.
Bake: Bake for 3 to 4 hours, or until the jerky is dry and firm but still pliable.
Cool and Store: Allow the beef jerky to cool completely before storing in an airtight container.